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Fetal Aneuploidy Screening Mastery

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Choroid Plexus Cysts (CPCs)

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Focuses on identifying cysts within the choroid plexus of the fetal brain. This module clarifies the association between CPCs and Trisomy 18 and provides guidance on when these findings require a more detailed cardiac or structural survey.

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Complete this lesson and pass the quiz to earn 10 Karma Points and move one step closer to your Fetal Aneuploidy Screening Mastery Certification.

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1. Choroid plexus cysts are transient and are virtually only observed within which gestational age window?
10–15 weeks 16–21 weeks 22–27 weeks 28–33 weeks
2. By which gestational week do choroid plexus cysts typically begin to undergo regression?
18th week 20th week 23rd week 28th week
3. Which of the following correctly describes the morphological variability of choroid plexus cysts?
Always unilateral and solitary Always bilateral and multiple Can be small or large, unilateral or bilateral, solitary or multiple Always confined to the posterior horn
4. What is the typical size range of choroid plexus cysts, and what is their most common internal appearance?
0.1–0.4 cm, unilocular 0.5–2 cm, multilocular 2–4 cm, simple >4 cm, complex
5. A large choroid plexus cyst may pose which specific diagnostic challenge?
It may be mistaken for an arachnoid cyst It may mimic ventriculomegaly It may obscure measurement of the cisterna magna It may appear as a Dandy-Walker variant
6. Choroid plexus cysts have been specifically linked in the literature to an increased risk for which chromosomal aneuploidy?
Trisomy 21 Trisomy 13 Trisomy 18 Monosomy X
7. Approximately what proportion of Trisomy 18 fetuses are observed to have choroid plexus cysts?
1 in 10 1 in 4 1 in 3 1 in 2
8. When should invasive testing be offered to a fetus identified with choroid plexus cysts?
Always, regardless of other findings Only if cysts exceed 2 cm When additional sonographic abnormalities are identified Never — CPCs are always benign
9. What is required to confidently classify a choroid plexus cyst as "isolated"?
Absence of other soft markers only A thorough fetal anatomic assessment, ruling out all structural abnormalities A normal maternal serum screen Confirmed cyst regression on follow-up
10. When a CPC is confirmed to be truly isolated after comprehensive assessment, is invasive testing generally warranted?
Yes, always No — the risk of aneuploidy is very low in truly isolated CPCs Only in advanced maternal age Only if bilateral