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The Genetic Sonogram

This session introduces the second-trimester genetic sonogram. Students will learn to combine various soft markers with maternal age and biochemical data to refine aneuploidy risk and determine the appropriate clinical pathway for further testing.


Mastery Reward

Complete this lesson and pass the quiz to earn 10 Karma Points and move one step closer to your Fetal Aneuploidy Screening Mastery Certification.

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1. What percentage of Down syndrome fetuses show serious structural defects on second-trimester sonography?
3. Approximately what fraction of prenatally identified duodenal atresia cases are associated with trisomy 21?
4. In second-trimester pregnancies with cystic hygroma, approximately what percentage are aneuploid — and which karyotype predominates?
6. What lateral ventricle atrial diameter defines cerebral ventriculomegaly on ultrasound?
7. What is the aneuploidy risk associated with a median cleft lip and palate?
8. What is the threshold for an abnormal nuchal fold in the second trimester, and during which gestational window is it measured?
9. When using femur length as a Down syndrome marker, what should the actual measurement be compared against?
10. What is the increased risk of trisomy 21 when BOTH humerus AND femur are short?