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Fetal Aneuploidy Screening Mastery

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The Nuchal Fold (NF)

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Master the measurement of the nuchal fold, a vital second-trimester marker. Students will learn the correct anatomical landmarks and step-by-step techniques for measurement, understanding how abnormal thickness correlates with Trisomy 21 and 18.

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Complete this lesson and pass the quiz to earn 10 Karma Points and move one step closer to your Fetal Aneuploidy Screening Mastery Certification.

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1. What percentage of newborns with Down syndrome display excess soft tissue or redundant skin folds in the posterior
33% 50% 80% 100%
2. Besides trisomy 21, which chromosomal disorders are associated with nuchal thickening?
Trisomy 13 only Turner syndrome only Turner syndrome, trisomy 18, and trisomy 13 Trisomy 18 and trisomy 13 only
3. Which non-chromosomal condition can produce nuchal thickening as a sequela?
Anencephaly Ventriculomegaly Resolved cystic hygroma Spina bifida
4. A key study reported that a nuchal fold of ≥ ___ mm was present in 33% of fetuses with Down syndrome.
4 mm 5 mm 6 mm 8 mm
5. Which imaging plane is used to obtain the nuchal fold thickness measurement?
Sagittal Coronal Transaxial Oblique
6. Which anatomical landmark must be confirmed in the imaging plane before measuring the nuchal fold?
Corpus callosum and thalami Sylvian fissure and caudate Cisterna magna and cerebellar hemispheres Cavum vergae and lateral ventricles
7. Where are calipers placed to measure the nuchal fold?
Inner skull table → inner skin border Inner skull table → outer skin border Outer skin border → outer skin border Exterior skull table → outer skin border
8. Between which gestational weeks is the nuchal fold measurement considered valid?
11–14 weeks 4–18 weeks 15–21 weeks 20–24 weeks
9. What nuchal fold measurement is classified as abnormal or increased in the second trimester?
≥ 4 mm ≥ 4.5 mm ≥ 5–6 mm ≥ 7 mm
10. If a previously thickened nuchal fold resolves spontaneously during pregnancy, should amniocentesis still be offered?
No — resolution confirms a normal karyotype No — only if other soft markers persist Yes — regression does not exclude trisomy 21 Only if the patient is high-risk by maternal age